Aortic disease. A study[1] published in November 2015 examined the association between fluoroquinolones, including ciprofloxacin, and aortic disease. This nested case/control study examined 1477 patients hospitalized with aortic dissection or aneurysm and 147,700 controls identified from Taiwan's National Health Insurance Research Database. Exposure to current or past fluoroquinolone used was evaluated. After propensity-score adjustment, current use of fluoroquinolones was found to be associated with increased risk for aortic aneurysm or dissection (relative risk [RR], 2.43; 95% confidence interval [CI], 1.83-3.22). Past use was also associated with risk, though on a smaller scale (RR, 1.48; 95% CI, 1.18-1.86).

Source: Medscape: Medscape Access