LAS VEGAS — In the first year after a postmenopausal women discontinues hormone therapy, her risk for cardiovascular mortality is higher than if she had continued the therapy, according to an observational study.

Hormone therapy guidelines for postmenopausal women recommend the lowest dose for the briefest period. "This has led to the clinical practice of pulling women off hormone therapy annually or biannually," said lead author Tomi Mikkola, MD, from the Helsinki University Central Hospital in Finland.