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Thread: The Skipper's Law

  1. #1
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    Default The Skipper's Law

    Law 1

    The doubling time of proliferating cancer cells is a constant, forming a straight line on a semi log plot.

    Law 2

    Cell kill by drugs follows first-order kinetics; that is, the percentage of cells killed at a given drug dose in a given tumor is a constant, regardless of the body burden of tumor cells.

    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease. Chengdu, Sichuan, China.

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    It may be that simple Skipper model applies to an occasional human malignancy that is readily curable by chemotherapy in early stage disease. Trophoblastic neoplasms, testicular germ cell tutors, and Burkitt lymphoma come to mind. Many have even hoped that the micrometastases of some common tutors behave similarly. However, few human cancers are composed of such highly responsive proliferating cells.

    In solid tumors in animals and overwhelmingly in humans, Skipper's law apply only to proliferating or stem cell compartment within the tumor, the fraction of cells within the total tumor that is actively growing.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease. Chengdu, Sichuan, China.

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  3. #3
    PharmD Year 1 TomHsiung's Avatar
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    Because Skipper's law apply only to the proliferating fraction, it is clear that the best opportunity to achieve total cell kill is in the early portion of the curve, when growth fraction is at a maximum.

    The maximum measurable tumor response is seen at midportion of the curve, where the growth rate is greatest. This is the best place to estimate drug efficacy against a particular tumor.

    A comparable kill of proliferating cells at the upper portion of the curve is unlikely to show a measure response because the growth rate is so small.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

  4. #4

    Exclamation How to prove the law

    Clinical Pharmacy Specialist - Infectious Diseases

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