Cytogenetics in Hematologic Malignancies

[CheneyHsiung]

Example, Acute Myeloid Leukemia

Slovak et al., stratified patients with AML into four risk categories.

Those in the favorable group had inv(16), t(15;17) or t(8;21).

While those in the unfavorable group had monosomy 5/5q deletion, monosomy 7/7q deletion, inv(3), 11q23 rearrangements, abnormalities of 17p, 20q or 21q, t(6;9), or complex karyotypes (with 3 or more abnormalities)

Those in the intermediate group had a normal karyotype, trisomy 8, trisomy 6, deletion of the 12p, or loss of the Y chromosome.

There was also an indeterminant group that contained all other chromosome anomalies.

Grimwade et al. proposed a slightly different prognostic classification scheme.

Individuals with inv(16), t(15;17) or t(8;21) were in the favorable group.

Those in the adverse group included abnormalities of 3q [excluding t(3;5)(q21-25;q31-35)], inv(3), monosomy 5/5q deletion, monosomy 7/7q deletion, t(6;11), t(10;11), 11q23 rearrangements [excluding t(9;11) and t(11;19)], t(9;22), monosomy 17/abnormalities of 17p, and complex karyotypes (with 4 or more abnormalities).

All others fell into the intermediate group