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Thread: Hemodynamic and oxygen transport parameters

  1. #1

    Thumbs up Hemodynamic and oxygen transport parameters

    1.CVP=RAP=RVEDP[mm Hg]

    CVP: Central Venous Pressure, RAP: Right Atrial Pressure, RVEDP: Right-ventricular End-diastolic Pressure

    2.PAWP=LAP=LVEDP [mm Hg]

    PAWP: Pulmonary Artery Wedge Pressure, LAP: Left Atrial Pressure, LVEDP: Left-ventricular End-diastolic Pressure

    3.CI=CO/BSA [L/min/m2]

    CI: Cardiac Index, CO: Cardiac Output, BSA: Body Surface Area

    4.SI=CI/HR [mL/m2]

    SI: Stroke Index, CI: Cardiac Index, HR: Heart Rate

    5.SVRI=(MAP-CVP)/CI [mm Hg/L/min/m2]

    SVRI: Systemic Vascular Resistance Index, MAP: Mean Arterial Pressure, CVP: Central Venous Pressure, CI: Cardiac Index

    6.PVRI=(PAP-PAWP)/CI [mm Hg/L/min/m2]

    PVRI: Pulmonary Vascular Resistance Index, PAP: Mean Pulmonary Arterial Pressure, PAWP: Pulmonary Artery Wedge Pressure, CI: Cardiac Index

    7.DO2=CI*CaO2=CI*(1.3*Hb*SaO2) [mL/min/m2]

    DO2: Oxygen Delivery, CI: Cardiac Index, CaO2: Oxygen Concentration in Arterial Blood, Hb: Hemoglobin Concentration, SaO2: Percent Saturation of Hemoglobin with Oxygen

    8.VO2=CI*(CaO2-CvO2)=CI*1.3*Hb*(SaO2-SvO2) [mL/min/m2]

    VO2: Oxygen Uptake, CI: Cardiac Index, CaO2: Oxygen Concentration in Arterial Blood, CvO2: Oxygen Concentration in Venous Blood, Hb: Hemoglobin Concentration, SaO2: Percent Saturation of Hemoglobin with Oxygen in Arterial Blood, SvO2: Percent Saturation of Hemoglobin with Oxygen in Venous Blood.

    Variability of VO2

    Each of the 4 measurements used to derive the VO2 has an inherent variability, which makes the summed variability of the calculated VO2 as high as 18%. Therefore, the VO2 that is calculated from the modified Fick equation must change by at least 18% for the change to be considered significant.

    9.O2ER=VO2/DO2(*100) [%]

    O2ER: Oxygen Extraction Ratio, VO2: Oxygen Uptake, DO2: Oxygen Delivery

    Table 1 Hemodynamic and Oxygen Transport Parameters



    Table 10.3
    Variability of Measurements Related to VO2

    Hemodynamic and oxygen transport parameters-screen-shot-2015-03-03-at-9-43-21-pm-png

    Table Normal Values of Maximal Oxygen Uptake at Different Ages
    Hemodynamic and oxygen transport parameters-screen-shot-2016-02-04-at-4-33-40-pm-png

    Table Ventricular Volumes
    Hemodynamic and oxygen transport parameters-screen-shot-2016-06-08-at-9-59-31-pm-png
    Attached Images Attached Images
    Last edited by admin; Wed 8th June '16 at 10:02pm.
    Clinical Pharmacy Specialist - Hematology

  2. #2
    PharmD Year 1 TomHsiung's Avatar
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    Default Lactate Level

    The initial lactate level (prior to treatment) of above 2 mol/L is involved with a increase in the in-hospital mortality. A dramatic increase in mortality rate in the first 3 days is shown when the initial lactate level is >= 4 mmol/L.

    The relationship between the rate of lactate clearance and the mortality rate shows that the lowest mortality rate occurs when lactate levels normalises within 24 hours, and the mortality rate increases dramatically when lactate levels does not normalise within 48 hours. Studies show that a lactate clearance >10% in the first 6 hours after diagnosis is associated with improved survival.

    Hemodynamic and oxygen transport parameters-screen-shot-2015-03-10-at-2-35-25-pm-jpg
    Last edited by TomHsiung; Tue 10th March '15 at 2:49pm.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

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    PharmD Year 1 TomHsiung's Avatar
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    Default Arterial Base Deficit

    Arterial base deficit has been a popular marker of impaired tissue oxygenation in acute surgical emergencies, especially trauma.

    The "base deficit" is defined as the amount (in millimoles) of base must be added to one later of blood to raise the pH to 7.40 (at a PCO2 of 40 mm Hg).

    The normal arterial base deficit is <=2 mol/L. Increases above 2 mol/L are classified as mild (2 to 5 mmol/L), moderate (6 to 14 mol/L), and severe (>= 15 mol/L).

    When used as a marker of tissue oxygenation, the arterial base deficit is a surrogate measure of serum lactate levels. However, base deficit is not specific for lactate because it is influenced by other causes of metabolic acidosis (e.g., ketosis, renal insufficiency).
    Last edited by TomHsiung; Tue 10th March '15 at 3:01pm.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

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    Default

    Well, it is important to know the reference range of oxygen parameters, not only for physicians but also for pharmacists.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease. Chengdu, Sichuan, China.

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