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Thread: IMPROVE-IT: 'Modest' Benefit When Adding Ezetimibe to Statins in Post-ACS Patients

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    PharmD Year 1 TomHsiung's Avatar
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    Default IMPROVE-IT: 'Modest' Benefit When Adding Ezetimibe to Statins in Post-ACS Patients

    Michael O'Riordan
    November 21, 2014


    CHICAGO, IL ( updated ) — More than 9 years since the IMPROVE-IT study was launched, physicians now have their answer when it comes to using ezetimibe (Zetia, Merck/Schering-Plough) in clinical practice. The large-scale, long-delayed, and controversial study of ezetimibe in post–acute-coronary-syndrome (ACS) patients showed a "modest" benefit in reducing cardiovascular events when ezetimibe was added to simvastatin in this population.

    Over a period of 7 years, the addition of ezetimibe to simvastatin 40 mg reduced the primary end point—a composite of cardiovascular death, MI, unstable angina requiring rehospitalization, coronary revascularization, or stroke—by 6.4% when compared with patients who received simvastatin alone (P =0.016). The absolute reduction in risk over 7 years was 2.0%, with 32.7% in the ezetimibe/simvastatin arm experiencing a primary end point compared with 34.7% in the simvastatin arm.

    Source: http://www.medscape.com/viewarticle/...80112PN&spon=2
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

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    PharmD Year 1 TomHsiung's Avatar
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    IMPROVE-IT: 'Modest' Benefit When Adding Ezetimibe to Statins in Post-ACS Patients-fig5-jpg

    IMPROVE-IT: 'Modest' Benefit When Adding Ezetimibe to Statins in Post-ACS Patients-fig6-jpg

    IMPROVE-IT: 'Modest' Benefit When Adding Ezetimibe to Statins in Post-ACS Patients-fig7-jpg
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

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