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Thread: Rash

  1. #1
    PharmD Year 1 TomHsiung's Avatar
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    Jan 2013
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    Chengdu, Sichuan, China
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    Default Rash

    Some Important Definitions
    Macule: lesion without elevation or depression, < 1cm
    Patch: lesion without elevation or depression, > 1 cm

    Papule: any solid, elevated "bump" < 1 cm
    Plaque: raised plateau-like lesion of variable size, often a confluence of papules

    Nodule: solid lesion with palpable elevation, 1-5 cm

    Tumor: solid growth, > 5 cm

    Cyst: encapsulated lesion, filled with soft material

    Vesicle: elevated, fluid-filled blister, < 1 cm
    Bulla: elevated, fluid-filled blister, > 1 cm
    Pustule: elevated, pus-filled blister, any size

    Wheal: inflamed papule or plaque formed by transient and superficial local edema

    Comedone: a plug of keratinous material and skin oils retained in a follicle; open is black, closed is white

    Differential Diagnosis
    • Papulosquamous eruptions (papules and plaques)
      • Eczematous dermatitis
        • Atopic dermatitis
        • Allergic contact dermatitis
        • Irritant contact dermatitis

      • Pityriasis rosea
      • Tinea infections
      • Psoriasis
      • Seborrheic dermatitis

    • Folliculopapular eruptions (perifollicular papules)
      • Acne vulgaris
      • Rosacea
      • Folliculitis
      • Perioral dermatitis

    • Dermal reaction patterns
      • Urticaria
      • Sarcoidosis
      • Granuloma annulare
      • Erythema nodosum

    • Purpura and petechiae
      • Palpable purpura
        • Leukocytoclastic vasculitis
          • Henoch-Schonlein purpura
          • Allergic vasculitis

        • Infectious
          • Bacteremia
          • Rocky Mountain spotted fever
          • Meningococcemia

      • Nonpalpable purpura
        • Thrombocytopenia
        • Medication-related
        • Benign pigmented purpura
        • Bacteremia
        • Disseminated intravascular coagulation
        • Actinic/senile purpura
        • Corticosteroid-assocaited
        • Amyloidosis

    • Bilstering disorders (vesicles, pustules, and bullae)
      • Autoimmune
        • Bullous pemphigoid
        • Pemphigus vulgaris
        • Epidermolysis bullosa acquisita

      • Infectious
        • Varicella zoster
        • Herpes simplex
        • Impetigo
        • Staphylococcal scalded skin

      • Hypersensitivity syndrome
        • Stevens-Johnson syndrome
        • Toxic epidermal necrolysis


    Pivotal Points

    • Morphology of the primary lesion
    • Distribution of lesions


    Rash-screen-shot-2017-04-18-at-8-42-39-pm-png
    Last edited by TomHsiung; Tue 18th April '17 at 9:45pm.
    B.S. Pharm, West China School of Pharmacy, Class of 2007, Health System Pharmacist, RPh. Hematology, Infectious Disease.

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